From the north: take the autostrada dal sole (A1) between Florence and Rome, and exit at Valdichiana (exit 28).
From the south: take the autostrada del Sole (A1), between Rome and Florence, and exit at Chiusi/Chianciano Terme (exit 29).
By train:
Rome/Florence line, alight at Chiusi/Chianciano Terme station. There is a bus link to Montepulciano.
Chiusi/Siena line, alight at Montepulciano Scalo station. There is a bus link to Montepulciano.
By air:
The nearest airports are Florence (125km), Pisa (190km), and Rome (200 km).
Useful distances (km):
Montepulciano 2, Perugia 73, Arezzo 62, Siena 65, Florence 120, Orvieto 55, Rome 180, Chiusi 24, Pienza 15, Cortona 32, Montalcino 38, Assisi 95.